ORC ID , Mohsen Arbabi1 ORC ID , Mahdi Mosayebi2, Hossein Hooshyar1, Ali Mohammad Nickfarjam3">
  • Users Online: 194
  • Print this page
  • Email this page
Year : 2021  |  Volume : 8  |  Issue : 1  |  Page : 45-50

Evaluation of anti-helmintic activity of Zingiber officinale roscoe extract on Fasciola hepatica miracidia In vitro

1 Department of Medical Parasitology, Kashan University of Medical Sciences, Kashan, Iran
2 Department of Medical Parasitology, Arak University of Medical Sciences, Arak, Iran
3 Department of Health Information Management and Technology, Faculty of Paramedicine, Kashan University of Medical Sciences, Kashan, Iran

Correspondence Address:
Prof. Mohsen Arbabi
15th Khordad Square, Abazar Street, P.O. Box: 87137.81147, Kashan
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/iahs.iahs_143_20

Rights and Permissions

Aims: The control of fascioliasis has depended on the utilization of a predetermined number of anthelmintic drugs. Nonetheless, the resistance of antifasciolid is presently boundless, and there is a need for potential drug properties of medicinal plants as new medications against Fasciola spp. to interrupt the parasite transmission. Materials and Methods: This investigation is meant to assess the potential anti-fasciolicide impacts of Zingiber officinale roscoe hydroalcoholic extract against the Fasciola miracidia. The eggs of Fasciola hepatica were gathered from the livers contaminated goats and sheep and washed 20 times with chlorine-free water, and afterward incubated at different pH, temperature, and light density for embryonic development. Concentrated miracidia of Fasciola spp. were incubated at different concentrations (2, 5, and 10 μg/mL) of hydroalcoholic extract of Z. officinale at different time intervals. The data were analyzed using the ANOVA statistical test. Results: The extract at different concentrations showed antifasciolid effects in comparison to triclabendazole. This braking action was dose-proportional and further related firmly to the disclosure time ( P < 0.001). In concentration of 10ug/ml extract killed the parasites at 105 ± 3 s ( P < 0.001). Conclusion: In vitro antimiracidia activities of the hydro alcoholic extract of Z. officinale was satisfactory and potent fasciolicide effective, however, in vivo impact of this extract, remains for extra assessment. In this manner, these therapeutic plant extracts might be seen as confident origins of bioactive composites that could be matured against miracidia. This is the main work to evaluate the potential enemy of fasciolicide impact of certain plants against Fasciola miracidia.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded97    
    Comments [Add]    

Recommend this journal