ORC ID , Akram Ranjbar2, Nejat Kheiripour3, Alireza Soltanian4, Mohammad Javad Assari5 ORC ID ">
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ORIGINAL ARTICLE
Year : 2020  |  Volume : 7  |  Issue : 2  |  Page : 84-88

Potential in the diagnosis of oxidative stress biomarkers in noninvasive samples of urine and saliva and comparison with serum of persons exposed to crystalline silica


1 Occupational Health, Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
2 Medical Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
4 Modeling of Noncommunicable Diseases Research Center, School of public health, Hamadan University of Medical Sciences, Hamadan, Iran
5 Associate Professor, Research Center for Health Sciences, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

Correspondence Address:
Dr. Mohammad Javad Assari
Occupational Health and Safety Research Center, School of Public Health, Hamadan University of Medical Sciences, Hamadan
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/iahs.iahs_37_19

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Background: Prolonged exposure to crystalline silica (CS) (SiO2) dust enhances the production of reactive oxygen species. In many studies, oxidative stress has been measured in the serum of workers exposed to SiO2dust. Aims: We investigated the body fluids such as urine, saliva, and serum, which can provide very good results for assessing the health status of workers' exposures to SiO2dust. Materials and Methods: The oxidative stress biomarkers were evaluated in serum, urine, and saliva of 21 workers who were exposed to SiO2silica crushing factories in the Hamadan city at the west of Iran as a case group and 28 controls. Results: The level of malondialdehyde in serum, urine, and saliva was significantly higher than that in case group compared to controls (22.19 ± 8.70, 9.86 ± 5.43, and 9.41 ± 7.31 nmol/L vs. 7.30 ± 2.22, 6.79 ± 3.21, and 3.93 ± 3.73 nmol/L, respectively). In addition, the total antioxidant capacity in urine (0.23 ± 0.06 vs. 0.29 ± 0.08 mmol/L), as well as catalase in the serum and saliva of case group was lower than that compared to control group (5.46 ± 1.56 and 1.32 ± 0.55 IU/L vs. 12.55 ± 5.72 and 2.32 ± 1.53 IU/L, respectively). Conclusions: The current study indicated that chronic exposure to SiO2affects significantly on the oxidative stress biomarker levels in serum, urine, and saliva in persons exposed. Furthermore, SiO2leads to the induction of oxidative stress and decreases the activity of the antioxidant enzyme.


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